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Amitriptyline is used for the treatment of mental or mood problems such as depression. This medicine may help improve feelings of well-being and mood, relieve tension and anxiety. Help you sleep better, and increase your energy level. Amitriptyline belongs to a class of medications known as tricyclic antidepressants.

Amitriptyline belongs to a class of medications known as tricyclic antidepressants. It works on the central nervous system to increase certain chemicals in the brain, which improves depression.

The main benefit of using Amitriptyline is the improvement it brings to the mood and feelings of well-being. It effectively relieves tension and anxiety. Amitriptyline helps you sleep better and increase your energy level.

Strictly follow the instructions of your doctor on how to use this medication. It will also help if you will read first the Patient Information Leaflet that comes with the medication package before you start using the product. If you have any questions, consult your doctor or pharmacist.

Take Amitriptyline orally, usually one to four times daily or as directed by your doctor. If you will take this medication only once daily, take it at bedtime to help reduce daytime sleepiness. The dosage of this medication was prescribed to you based on your medical condition and your response to the treatment.

Your doctor may ask you to start this medication at a low dose and gradually increase it in order to reduce your risk of side effects such as dizziness, drowsiness, or dry mouth.

You can get the most benefit from this medication if you will take it on a regular basis. It will help you remember your doses if you will take them at about the same time each day.

Do not increase your dose or use this medicine more often or for longer than what is prescribed by your doctor. Your condition will not improve any faster by increasing the dose or taking it longer. You will increase your risk of side effects.

Continue taking this medication even if you start feeling well. Do not stop taking this medication without first consulting your doctor. Some conditions may worsen when you suddenly stop taking this medicine. You may experience symptoms such as a headache, mood swings, sleep change, and tiredness. To prevent these symptoms while you are stopping treatment with this medicine, your doctor may reduce your dose gradually. Report to your doctor any new or worsening symptoms right away.

Amitriptyline may not work immediately. You can expect some benefit within a week. It may take up to 4 weeks before you feel the full effect of this medicine.

Report to your doctor when your condition gets worse or persists such as your feelings of sadness getting worse, or having suicidal thoughts.


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Usual dosage of Amitriptyline for depression:

For adults between the ages of 18 and 64:

  • Starting dose - 75 mg per day, usually in divided doses.
  • Dosage increases - your doctor will slowly increase your dosage if necessary.
  • Maximum dosage - 15o mg per day
  • Alternative dosage regimen - Start with 50 to 100 mg at bedtime, to be increased by 25 or mg as needed in the bedtime dose, for a total of 150 mg per day.

Child dosage between the ages 0 to 17:

It has not been confirmed that this medication is safe and effective for use in children younger than 17 years.

Senior dosage at ages 65 years and older:

The kidneys of older adults may not work as well as they used to. This could result in the body processing drugs more slowly, with more of a drug staying in your body for a longer time. This raises your risk of side effects. Your doctor may lower your dose or give you a different dosing schedule. This will prevent this drug from building up in your body.

Amitriptyline can cause drowsiness and dizziness during the first few hours of taking it. If you notice drowsiness while you take this drug, your doctor may ask you to take the dose at bedtime.

This medication can cause other side effects.

The following are the more common side effects of amitriptyline:

  • A headache
  • Numbness and tingling in the arms and legs
  • Confusion
  • Blurred vision
  • Constipation or diarrhoea
  • Skin rash
  • Nausea
  • Swelling of your face and tongue
  • Unexpected weight gain or loss

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