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What Is Contrave (Mysimba)?

Contrave (Mysimba) is a new weight loss medication that has been developed by Orexigen Therapeutics in the US. Contrave (Mysimba) contains Bupropion and Naltrexone as the active ingredients. The Contrave (Mysimba) diet pill affects how the brain and central nervous system regulate appetite, food cravings, energy expenditure and, in turn, body weight.

How Does Contrave (Mysimba) Work?

The new slimming agent works by combining two different active substances. It will create a synergy effect that will make the drug more effective than other means of weight control.
The active substances in Contrave (Mysimba) are Bupropion and Naltrexon, which are already known by EMA and are used in other contexts. The drug comes in tablet form and releases substances in a prolonged process, so you can experience the effect over a longer period of time. Opposite the existing slimming agent, Xenical, Mysimba seems to affect the desire for food. The active substances affect the places in the brain where become governed elements such as food intake, energy consumption, and the reward mechanisms you experience in connection with dining.
Bupropion works by affecting the body’s levels of dopamine, which reduces one’s appetite while the body needs to be active.
Naltrexone helps to continue weight loss when the effect of bupropion begins to decrease. In addition, the drug ensures that some things will not taste so good, including sweet things.

How to take Contrave (Mysimba)

Initially 1 tablet daily for 7 days, then increased to 1 tablet twice daily for 7 days, then increased to 3 tablets daily in divided doses for 7 days, two tablets to be taken in the morning, and one tablet to be taken in the evening, then maintenance 2 tablets twice daily, review treatment after 16 weeks and then annually.

Side Effects of Contrave (Mysimba)

As with all medications, some side effects were noted. Here are the most common side effects:

  • ● Anxiety
  • ● Insomnia
  • ● Headache
  • ● Restlessness
  • ● Dizziness
  • ● Concentration disturbance
  • ● Palpitations
  • ● Hot flush
  • ● Nausea
  • ● Constipation
  • ● Muscular pain

It should be noted that most patients did not get any side effects but all side effects should be reported to the prescribing doctor in case it is appropriate to recommend cessation of treatment. Blood pressure should be monitored regularly while undergoing treatment with Contrave (Mysimba).

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