Orlistat vs Rybelsus (Semaglutide) Weight Loss

Orlistat (brand names: Xenical, Alli) and semaglutide (brand name: Rybelsus) are both medications that can be used to help with weight loss. Orlistat works by preventing the absorption of some of the fat from the food you eat, while semaglutide works by decreasing appetite and increasing feelings of fullness.


Both medications have been shown to be effective for weight loss. In clinical trials, people taking orlistat lost an average of about 5-10% of their body weight over the course of a year, while those taking semaglutide lost an average of about 10-20% of their body weight over the same period of time.


It's important to note that weight loss medications are generally most effective when used in combination with a healthy diet and regular physical activity. It's also important to talk to your doctor before starting any weight loss medication, as they can have side effects and may not be suitable for everyone.