Buy Finacea Gel UK | What is Finacea Gel?

Finacea gel contains the active ingredient azelaic acid and belongs to the group of anti-acne preparations for external use (on the skin). Finacea gel is for the relief of mild to moderate papule-pustular acne of the facial area and for the treatment of papule-pustular rosacea. Papule-pustular acne and rosacea are associated with inflamed papules and pustules.

How does Finacea Gel work?

Acne:

The bases of the therapeutic efficacy of azelaic acid in acne are considered to be the antimicrobial action and the direct influence on follicular hyperkeratosis.

In vitro and in vivo, azelaic acid inhibits the proliferation of keratinocytes and normalizes altered terminal epidermal differentiation processes in acne.

Clinically, a significant reduction in the colonization density of Propionibacterium acnes and a significant reduction in the fraction of lipid-free fatty acids on the skin surface are observed.

In two randomized double-blind clinical studies, Finacea gel was significantly superior to its vehicle in reducing the median sum of papules and pustules and was 6% less effective than benzoyl peroxide 5% (p = 0.056).

In these studies, the effectiveness of comedones has been evaluated as a secondary parameter. Finacea gel was more effective than its vehicle in the relative reduction of median comedones and was less effective compared to benzoyl peroxide 5%.

Rosacea:

Although the pathophysiology of rosacea is not fully understood, there is a growing consensus that inflammation involving the elevation of various proinflammatory effector molecules such as kallikrein-5 and cathelicidin, as well as reactive oxygen species (ROS), is the central process. of this disease.

Azelaic acid has been shown to modulate the inflammatory response in normal human keratinocytes by:

activation of peroxisome activated receptor proliferators (PPAR);

inhibition of trans-activation of nuclear factor-kB (NF-kB);

inhibition of pro-inflammatory cytokine production and

inhibition of ROS release from neutrophils, as well as the effects of direct scanning on existing ROS.

In addition, azelaic acid has been shown to directly inhibit kallikrein-5 and cathelicidin expression in three in vitro models (human keratinocytes), in murine skin, and in the facial skin of patients with rosacea.

These anti-inflammatory properties of azelaic acid may play a role in the treatment of rosacea.

Although the clinical significance of these findings with respect to kallikrein-5 and cathelicidin and their impact on the pathophysiology of rosacea has not been fully demonstrated in a large-scale clinical study, initial studies on human facial skin appear to confirm the in vitro and murine findings.

How do I use Finacea Gel work?

For the treatment of rosacea, Finacea should be applied to the affected area twice a day - once in the morning and once in the evening. For best results, use the treatment at the same time each day.

Before applying Finacea, thoroughly wash the area of application with warm water and a mild soap.

1. Pat dry the area before applying Finacea gel.
2. Apply a pea-sized amount of Finacea gel (about an inch) to the face and massage into the affected area. Avoid contact with your eyes.
3. Always wash your hands after using Finacea 15% gel.
4. It’s important to use Finacea as prescribed by your doctor.

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