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Used for the treatment of Diabetes

  • Effective diabetes medication
  • Manages blood sugar levels
  • Aids weight loss
From £131.98

Xigduo is an oral anti-diabetic, used in the treatment of type 2 diabetes.

Those with type 2 diabetes have pancreas’ that do not make enough insulin, or their bodies simply aren’t able to use it properly. Because insulin is linked to the level of sugar in your blood, diabetic people end up with a much higher amount, which Xigduo works to lower and control.

Diabetes is a lifelong illness, although type 2 often doesn’t develop until later in life and is linked to being overweight or inactive. Symptoms can include excessive thirst, frequent urination and extreme tiredness or fatigue.

It’s important to manage the disease, as it can cause serious health problems with your eyes, heart and nervous system, and Xigduo will help you do this.

Xigduo is a prescription-only medication. Always follow the advice of your doctor and read the patient information leaflet provided in the medication packet.

Take the tablets by swallowing whole with a drink of water, at the same time as food to lower the risk of an upset stomach (side effect). You can take it at any time of day, however keeping your chosen time consistent will help you remember to take it.

Xigduo contains the active ingredients dapagliflozin and metformin, in strengths of either 5 mg/850 mg or 5 mg/1,000 mg respectively, per tablet.

The normal dose is one tablet twice a day, however your doctor will decide which dose is best based on your personal circumstances.

If you forget to take your Xigduo tablet then you should take it as soon as you remember, unless it’s nearly time for your next tablet. In this case, you should skip the forgotten dose and move straight onto the next one, as you should never take a double dose.

If you take more Xigduo than you should, then go to your doctor or nearest emergency department immediately, as it can cause lactic acidosis, a serious condition that can lead to a coma. Symptoms include feeling or being sick, stomach ache with muscle cramps and severe tiredness or difficulty breathing.

Before taking Xigduo, you should always first consult your doctor. You should not take Xigduo if any of the following apply to you:

  • if you are allergic to dapagliflozin, metformin or any of the other ingredients of this medicine
  • if you have ever had a diabetic coma
  • if you have uncontrolled diabetes, with, for example severe hyperglycaemia
  • if you have severely reduced kidney function
  • if you have a severe infection
  • if you have lost a lot of water from your body
  • if you have recently had a heart attack or if you have heart failure
  • if you have problems with your liver
  • if you are 75 years old or older
  • if you are taking another medicine for diabetes that contains “pioglitazone”
  • if you drink large amounts of alcohol, either every day or only from time to time

Your prescription of Xigduo may also be affected by a number of other factors, so you should make your doctor aware if any of the following apply:

  • if you have “type 1 diabetes” – the type that usually starts when you are young, and your body does not produce any insulin
  • if you have problems with your kidneys
  • if you have very high levels of glucose in your blood which may make you dehydrated
  • if you are taking medicines to lower blood pressure and have a history of it
  • if you have a history of serious heart disease or if you have had a stroke
  • if you often get infections of the urinary tract
  • if you have an increase in the amount of red blood cells in your blood, seen in tests

Like many medications with active ingredients, Xigduo can affect or be affected by other medicines. Particular medications that you may experience this with include the following:

  • medicines which increase urine production (diuretics)
  • medicines that lower the amount of sugar in your blood such as insulin or a “sulphonylurea” medicine
  • cimetidine, a medicine used to treat stomach problems
  • bronchodilators (beta-2 agonists) which are used to treat asthma
  • corticosteroids (used to treat inflammation)
  • medicines used to treat pain and inflammation
  • certain medicines for the treatment of high blood pressure

If you are taking any of the above medications, then you should make your doctor aware so that they can advise whether or not Xigduo will be the best course of action for you.

Like with all diabetic patients (regardless of treatment), you should also check your feet regularly and follow the foot care advice given by your doctor. You will also need regular kidney function tests while taking Xigduo.

If you are pregnant, breastfeeding or planning to have a baby then you should speak to your doctor as Xigduo is not advised during the second and third trimesters.

Even when taking this medicine, you will still need to follow a diet and exercise plan in order to keep your diabetes well-managed. Always follow the advice of your doctor, pharmacist or nurse and contact them if you are unsure. You should also avoid excessive alcohol intake because it can increase the risk of developing lactic acidosis.

The most common side effects of using Xigduo include:

  • urinary tract infections
  • nausea, vomiting, diarrhoea or stomach ache
  • loss of appetite
  • genital infection (thrush) of your penis or vagina
  • back pain
  • changes in urination, discomfort when passing urine
  • changes in the amount of cholesterol or red blood cells in your blood
  • changes in taste
  • dizziness
  • rash  

If you do experience one or more of these side effects and they persist or worsen, then inform your doctor right away. You should also contact your doctor if you notice any serious side effects, such as difficulty breathing, blurred vision, or severe and persistent abdominal pain.

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